SEQ Help Center

# Somatic Sample Analysis

# Dashboard

Somatic Dashboard

  • Case Information

    • (Mandatory) Case-ID/Name: Specific ID/Name created by the user to identify each case
    • (Optional) Age (1-150)
    • (Optional) Gender (female | male | unspecified)

  • Number of annotations: The number of variant annotations, off-target, and on-target counts are shown here.

  • Number of reads: The distribution of aligned/unaligned and off/on geneset reads are shown

  • Het/hom and Ts/tv ratio: The het/hom ratio and the ts/tv ratio of the sample are shown here together with the distribution of the values for all samples in the SEQ platform with the same machine/kit combination.

  • Target region coverage: The target refers to the regions defined in the kit. The coverage for different sequencing depths is shown for all chromosomes, and per chromosome.

  • Average depth: The average depth around the kit target regions

  • % of on target: The target region coverage for all chromosomes with 1X sequencing depth threshold. This is identical to the value illustrated in the target region coverage section.

  • Summary: In the summary table, drug resistance causing or drug sensitizing alterations and their related drugs are displayed with the level of evidence codes.

    • Columns
      • Alteration: Name of the gene or biomarker (PD-L1, TMB, MSI, etc.) and how it is altered (e.g. amino acid change, affected transcript position for spliced variant, copy number change, or high TMB)
      • Approved for the selected cancer type: List of FDA-approved drugs to treat the diagnosed condition by targeting the alteration or a downstream target. You can see the detailed summary for the drug by clicking each drug name.
      • Investigational for the selected cancer type: List of potential drugs that may target specified alterations or a downstream target and are being investigated as a potential therapy for the diagnosed condition. You can see the detailed summary for the drug and links to view the related clinical trials on ClinicalTrials.gov by clicking each drug name.
      • Approved for Other Indications: List of drugs that have not been approved to treat the diagnosed condition but have been approved to treat other cancer types.
      • Resistance: List of drugs to which at least one of the specified alterations is resistant.

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